If you replaced the entire nuclear payload with C4, a single standard reentry vehicle (the protective "cone" at the tip of the rocket) could hold roughly 450–600 lbs (200–270 kg) of the explosive.
A heavy-lift missile like the Trident II D5 could technically carry a total of 6,160 lbs (2,800 kg) of C4 if the entire payload deck were filled.
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